MolNFT v1 · #50250 · protein

Immunoglobulin 48G7 germline Fab-affinity maturation of an esterolytic antibody

2RCS: “Immunoglobulin 48G7 germline Fab-affinity maturation of an esterolytic antibody”. X-ray diffraction, 5 pockets (best druggability 0.65). MolNFT v1 #50250 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RCS
Type: protein
Length: 431 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Immunoglobulin 48G7 germline Fab
UniProt: P01857
Pockets: 5 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Immunoglobulin 48G7 germline Fab	protein	214	5% helix, 50% strand	—
H	Immunoglobulin 48G7 germline Fab	protein	217	11% helix, 51% strand	P01857

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	87	0.65	0.91	19	empty
2	456	0.61	0.76	43	empty
3	101	0.48	0.81	22	empty
4	61	0.29	0.74	16	empty
5	61	0.28	0.74	21	empty

Interfaces

1 interface between chains.

L–H · 1753 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

2RCS · Immunoglobulin 48G7 germline Fab-affinity maturation of an esterolytic antibody · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01857
Elsewhere: RCSB PDB 2RCS · PDBe 2RCS · UniProt P01857

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