MolNFT v1 · #5024 · protein
Apo saccharopine reductase from magnaporthe grisea
1E5L: “Apo saccharopine reductase from magnaporthe grisea”. X-ray diffraction, 7 pockets (best druggability 0.82). MolNFT v1 #5024 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1E5L
- Type
- protein
- Length
- 898 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Saccharopine reductase
- EC
- 1.5.1.10
- Pockets
- 7 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Saccharopine reductase (EC 1.5.1.10) | protein | 449 | 39% helix, 23% strand | — |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 953 | 0.82 | 0.83 | 105 | empty |
| 2 | 851 | 0.77 | 0.80 | 64 | empty |
| 3 | 928 | 0.74 | 0.77 | 66 | empty |
| 4 | 95 | 0.46 | 0.80 | 18 | empty |
| 5 | 165 | 0.42 | 0.74 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1118 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 1E5L · Apo saccharopine reductase from Magnaporthe grisea · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1E5L · PDBe 1E5L
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