MolNFT v1 · #50226 · protein

Cytochrome C peroxidase W191G in complex with 2,4,5-trimethyl-3- oxazoline

2RC1: “Cytochrome C peroxidase W191G in complex with 2,4,5-trimethyl-3- oxazoline”. X-ray diffraction, 2 ligands (HEM, 285), 2 pockets (best druggability 0.81). MolNFT v1 #50226 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RC1
Type: protein
Length: 292 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome C peroxidase
EC: 1.11.1.5
UniProt: A7A026
Ligands: HEM, 285
Pockets: 2 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Cytochrome C peroxidase (EC 1.11.1.5)	protein	292	49% helix, 7% strand	A7A026

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains X
285 · (2R,4R,5R)-2,4,5-trimethyl-1,3-oxazolidine · ligand · chains X

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	402	0.81	0.90	50	HEM, 285
2	111	0.42	0.77	23	empty

Compared structures

2RC1 · Cytochrome C Peroxidase W191G in complex with 2,4,5-trimethyl-3-oxazoline · the same entry in another collection · chain X against X, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A7A026
Elsewhere: RCSB PDB 2RC1 · PDBe 2RC1 · UniProt A7A026

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