MolNFT v1 · #50210 · protein
High resolution design of a protein loop
2RBL · Tenascin: “High resolution design of a protein loop”. X-ray diffraction, 3 pockets (best druggability 0.66). MolNFT v1 #50210 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2RBL
- Type
- protein
- Length
- 258 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tenascin
- UniProt
- P24821
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Tenascin | protein | 89 | 3% helix, 55% strand | P24821 |
| M | Tenascin | protein | 80 | 0% helix, 49% strand | P24821 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 220 | 0.66 | 0.85 | 29 | empty |
| 2 | 89 | 0.32 | 0.74 | 21 | empty |
| 3 | 55 | 0.29 | 0.75 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2257 Ų buried · 46 hydrogen bonds · protein-protein
- A–M · 695 Ų buried · 18 hydrogen bonds · protein-protein
- B–M · 44 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24821
- Elsewhere: RCSB PDB 2RBL · PDBe 2RBL · UniProt P24821
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