MolNFT v1 · #50199 · protein
Crystal structure of E.COLI hype
2RB9 · Hype protein: “Crystal structure of E.COLI hype”. X-ray diffraction, 15 pockets (best druggability 0.81). MolNFT v1 #50199 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2RB9
- Type
- protein
- Length
- 1,289 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hype protein
- UniProt
- Q7ABB2
- Pockets
- 15 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Hype protein | protein | 322 | 34% helix, 25% strand | Q7ABB2 |
| D | Hype protein | protein | 323 | 37% helix, 25% strand | Q7ABB2 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1149 | 0.81 | 0.82 | 104 | empty |
| 2 | 733 | 0.81 | 0.85 | 74 | empty |
| 3 | 680 | 0.75 | 0.81 | 65 | empty |
| 4 | 641 | 0.75 | 0.81 | 57 | empty |
| 5 | 448 | 0.72 | 0.82 | 49 | empty |
Interfaces
3 interfaces between chains.
- C–D · 2794 Ų buried · 49 hydrogen bonds · protein-protein
- A–B · 2704 Ų buried · 44 hydrogen bonds · protein-protein
- B–D · 572 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2RB9 · Crystal structure of E.coli HypE · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7ABB2
- Elsewhere: RCSB PDB 2RB9 · PDBe 2RB9 · UniProt Q7ABB2
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