MolNFT v1 · #50172 · protein

The px-bar membrane remodeling unit of sorting nexin 9

2RAI · Sorting nexin-9: “The px-bar membrane remodeling unit of sorting nexin 9”. X-ray diffraction, 9 pockets (best druggability 0.80). MolNFT v1 #50172 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RAI
Type: protein
Length: 731 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sorting nexin-9
UniProt: Q9Y5X1
Pockets: 9 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 67% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sorting nexin-9	protein	363	69% helix, 7% strand	Q9Y5X1
B	Sorting nexin-9	protein	368	66% helix, 7% strand	Q9Y5X1

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	126	0.80	0.97	30	empty
2	333	0.63	0.79	36	empty
3	323	0.62	0.79	37	empty
4	135	0.55	0.82	32	empty
5	115	0.53	0.82	26	empty

Interfaces

1 interface between chains.

A–B · 3196 Å² buried · 25 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 26 modified (engineered).

Compared structures

2RAI · The PX-BAR membrane remodeling unit of Sorting Nexin 9 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y5X1 · AlphaFold monomer V2.0 prediction for sorting nexin-9 (Q9Y5X1) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y5X1
Elsewhere: RCSB PDB 2RAI · PDBe 2RAI · UniProt Q9Y5X1

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