MolNFT v1 · #50159 · protein

Crystal structure of human monocyte chemoattractant protein 4 (mcp- 4/CCL13)

2RA4 · Small-inducible cytokine A13: “Crystal structure of human monocyte chemoattractant protein 4 (mcp- 4/CCL13)”. X-ray diffraction, 1 ligand (SO4). MolNFT v1 #50159 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RA4
Type: protein
Length: 130 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Small-inducible cytokine A13
UniProt: Q99616
Ligands: SO4

Structure

x-ray diffraction · 1 distinct chain · 20% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Small-inducible cytokine A13	protein	65	20% helix, 28% strand	Q99616

Ligands and binding sites

SO4 · Sulfate ion · ion · 6 copies · chains A, B
TFA · trifluoroacetic acid · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 1128 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2RA4 · Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13) · the same entry in another collection · chain A against A, TM-score 1.00
Q99616 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 13 (Q99616) · a predicted model of the same protein · chain B against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99616
Elsewhere: RCSB PDB 2RA4 · PDBe 2RA4 · UniProt Q99616

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