MolNFT v1 · #50085 · protein + RNA

Crystal structure of rotavirus SA11 VP1/RNA (ggcuuu) complex

2R7V · RNA (5'-R(*G*GP*CP*UP*UP*U)-3'): “Crystal structure of rotavirus SA11 VP1/RNA (ggcuuu) complex”. X-ray diffraction, 17 pockets (best druggability 0.85). MolNFT v1 #50085 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2R7V
Type: protein + RNA
Length: 1,078 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (5'-R(*G*GP*CP*UP*UP*U)-3'); RNA-dependent RNA polymerase
UniProt: O37061
Pockets: 17 · best druggability 0.85

Structure

x-ray diffraction · 2 distinct chains · 52% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	RNA (5'-R(GGPCPUPUPU)-3')	rna	5	—	—
A	RNA-dependent RNA polymerase	protein	1073	52% helix, 13% strand	O37061

Pockets

17 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1075	0.85	0.86	118	empty
2	621	0.75	0.82	56	empty
3	317	0.71	0.84	37	empty
4	458	0.66	0.79	42	empty
5	149	0.61	0.84	23	empty

Interfaces

1 interface between chains.

X–A · 625 Å² buried · 13 hydrogen bonds · protein-nucleic

Compared structures

2R7V · Crystal Structure of Rotavirus SA11 VP1/RNA (GGCUUU) Complex · the same entry in another collection · chain X against X, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O37061
Elsewhere: RCSB PDB 2R7V · PDBe 2R7V · UniProt O37061

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