MolNFT v1 · #50081 · protein + RNA

Crystal structure of rotavirus SA11 VP1/RNA (ugugacc) complex

2R7R · RNA (5'-R(*UP*GP*UP*GP*AP*CP*C)-3'): “Crystal structure of rotavirus SA11 VP1/RNA (ugugacc) complex”. X-ray diffraction, 17 pockets (best druggability 0.78). MolNFT v1 #50081 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2R7R
Type: protein + RNA
Length: 1,080 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (5'-R(*UP*GP*UP*GP*AP*CP*C)-3'); RNA-dependent RNA polymerase
UniProt: O37061
Pockets: 17 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	RNA (5'-R(UPGPUPGPAPCP*C)-3')	rna	7	—	—
A	RNA-dependent RNA polymerase	protein	1073	51% helix, 13% strand	O37061

Pockets

17 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	422	0.78	0.87	50	empty
2	244	0.77	0.90	41	empty
3	236	0.71	0.87	44	empty
4	324	0.70	0.84	37	empty
5	420	0.64	0.78	40	empty

Interfaces

1 interface between chains.

X–A · 998 Å² buried · 23 hydrogen bonds · protein-nucleic

Compared structures

2R7R · Crystal Structure of Rotavirus SA11 VP1/RNA (UGUGACC) complex · the same entry in another collection · chain X against X, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O37061
Elsewhere: RCSB PDB 2R7R · PDBe 2R7R · UniProt O37061

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