MolNFT v1 · #50078 · protein

Crystal structure of VP1 apoenzyme of rotavirus SA11 (N-terminal hexahistidine-tagged)

2R7O · RNA-dependent RNA polymerase: “Crystal structure of VP1 apoenzyme of rotavirus SA11 (N-terminal hexahistidine-tagged)”. X-ray diffraction, 13 pockets (best druggability 0.76). MolNFT v1 #50078 on GenesisL1: 3D structure, binding…

PDB: 2R7O
Type: protein
Length: 1,071 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-dependent RNA polymerase
UniProt: O37061
Pockets: 13 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-dependent RNA polymerase	protein	1071	52% helix, 10% strand	O37061

Pockets

13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	645	0.76	0.82	77	empty
2	293	0.74	0.87	43	empty
3	278	0.68	0.83	33	empty
4	177	0.59	0.82	31	empty
5	404	0.57	0.74	49	empty

Compared structures

2R7O · Crystal Structure of VP1 apoenzyme of Rotavirus SA11 (N-terminal hexahistidine-tagged) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O37061
Elsewhere: RCSB PDB 2R7O · PDBe 2R7O · UniProt O37061

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