MolNFT v1 · #50053 · protein
Crystal structure of the SAM-dependent methyltransferase NGO1261 from neisseria gonorrhoeae, northeast structural genomics consortium target NGR48
2R6Z · UPF0341 protein in rsp 3' region: “Crystal structure of the SAM-dependent methyltransferase NGO1261 from neisseria gonorrhoeae, northeast…”. X-ray diffraction, 4 pockets (best druggability 0.70). MolNFT v1 #50053 on GenesisL1: 3D…
- PDB
- 2R6Z
- Type
- protein
- Length
- 467 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- UPF0341 protein in rsp 3' region
- UniProt
- P72077
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | UPF0341 protein in rsp 3' region | protein | 225 | 38% helix, 24% strand | P72077 |
| B | UPF0341 protein in rsp 3' region | protein | 242 | 36% helix, 22% strand | P72077 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 547 | 0.70 | 0.80 | 73 | empty |
| 2 | 488 | 0.67 | 0.78 | 55 | empty |
| 3 | 52 | 0.35 | 0.79 | 12 | empty |
| 4 | 51 | 0.28 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1220 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 2R6Z · Crystal structure of the SAM-dependent methyltransferase NGO1261 from Neisseria… · the same entry in another collection · chain A against A, TM-score 1.00
- P72077 · AlphaFold monomer V2.0 prediction for ribosomal RNA small subunit methyltransferase J… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P72077
- Elsewhere: RCSB PDB 2R6Z · PDBe 2R6Z · UniProt P72077
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