MolNFT v1 · #50040 · protein

Crystal structure of rat CK2-beta subunit

2R6M · Casein kinase II subunit beta: “Crystal structure of rat CK2-beta subunit”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.73). MolNFT v1 #50040 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2R6M
Type: protein
Length: 357 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Casein kinase II subunit beta
UniProt: P67874
Ligands: ZN
Pockets: 1 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Casein kinase II subunit beta	protein	176	36% helix, 9% strand	P67874
B	Casein kinase II subunit beta	protein	181	37% helix, 8% strand	P67874

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	780	0.73	0.78	60	empty

Interfaces

1 interface between chains.

A–B · 382 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

2R6M · Crystal structure of rat CK2-beta subunit · the same entry in another collection · chain A against A, TM-score 1.00
P67874 · AlphaFold monomer V2.0 prediction for casein kinase II subunit beta (P67874) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P67874
Elsewhere: RCSB PDB 2R6M · PDBe 2R6M · UniProt P67874

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