MolNFT v1 · #49978 · protein

Crystal structure of the human BETA2 adrenoceptor

2R4S · Beta-2 adrenergic receptor: “Crystal structure of the human BETA2 adrenoceptor”. X-ray diffraction, 10 pockets (best druggability 0.71). MolNFT v1 #49978 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2R4S
Type: protein
Length: 647 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-2 adrenergic receptor; Antibody for BETA2 adrenoceptor, light chain; Antibody for…
UniProt: P07550
Pockets: 10 · best druggability 0.71

Structure

x-ray diffraction · 3 distinct chains · 22% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-2 adrenergic receptor	protein	216	57% helix, 0% strand	P07550
L	Antibody for BETA2 adrenoceptor, light chain	protein	214	5% helix, 45% strand	—
H	Antibody for BETA2 adrenoceptor, heavy chain	protein	217	4% helix, 47% strand	—

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	275	0.71	0.85	39	empty
2	758	0.68	0.76	62	empty
3	209	0.55	0.78	31	empty
4	141	0.49	0.78	21	empty
5	157	0.45	0.75	26	empty

Interfaces

3 interfaces between chains.

L–H · 1855 Å² buried · 14 hydrogen bonds · protein-protein
A–H · 480 Å² buried · 8 hydrogen bonds · protein-protein
A–L · 380 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

2R4S · Crystal structure of the human beta2 adrenoceptor · the same entry in another collection · chain A against A, TM-score 1.00
P07550 · AlphaFold monomer V2.0 prediction for beta-2 adrenergic receptor (P07550) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07550
Elsewhere: RCSB PDB 2R4S · PDBe 2R4S · UniProt P07550

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.