MolNFT v1 · #49956 · protein
Crystal structure of the protein of unknown function from enterococcus faecalis
2R41 · Uncharacterized protein: “Crystal structure of the protein of unknown function from enterococcus faecalis”. X-ray diffraction, 3 pockets (best druggability 0.67). MolNFT v1 #49956 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2R41
- Type
- protein
- Length
- 417 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein
- UniProt
- Q837L7
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 4 distinct chains · 21% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized protein | protein | 103 | 21% helix, 40% strand | Q837L7 |
| B | Uncharacterized protein | protein | 104 | 21% helix, 39% strand | Q837L7 |
| C | Uncharacterized protein | protein | 106 | 21% helix, 38% strand | Q837L7 |
| D | Uncharacterized protein | protein | 104 | 21% helix, 38% strand | Q837L7 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.67 | 0.78 | 82 | empty |
| 2 | 382 | 0.56 | 0.74 | 55 | empty |
| 3 | 53 | 0.28 | 0.75 | 17 | empty |
Interfaces
5 interfaces between chains.
- A–B · 664 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 607 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 601 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 255 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 252 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 2R41 · Crystal structure of the protein of unknown function from Enterococcus faecalis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q837L7
- Elsewhere: RCSB PDB 2R41 · PDBe 2R41 · UniProt Q837L7
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