MolNFT v1 · #49850 · protein
Structure of an acetylated RSC4 tandem bromodomain histone chimera
2R10 · Chromatin structure-remodeling complex protein RSC4…: “Structure of an acetylated RSC4 tandem bromodomain histone chimera”. X-ray diffraction, 8 pockets (best druggability 0.72). MolNFT v1 #49850 on GenesisL1: 3D structure, binding…
- PDB
- 2R10
- Type
- protein
- Length
- 591 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromatin structure-remodeling complex protein RSC4, linker, histone H3
- UniProt
- Q02206
- Pockets
- 8 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromatin structure-remodeling complex protein RSC4, linker, histone H3 | protein | 293 | 58% helix, 1% strand | Q02206 |
| B | Chromatin structure-remodeling complex protein RSC4, linker, histone H3 | protein | 298 | 57% helix, 2% strand | Q02206 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 387 | 0.72 | 0.83 | 38 | empty |
| 2 | 426 | 0.72 | 0.82 | 40 | empty |
| 3 | 68 | 0.46 | 0.82 | 15 | empty |
| 4 | 77 | 0.44 | 0.81 | 16 | empty |
| 5 | 157 | 0.43 | 0.74 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 266 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (acetylation).
Compared structures
- 2R10 · Structure of an acetylated Rsc4 tandem bromodomain Histone Chimera · the same entry in another collection · chain A against A, TM-score 1.00
- Q02206 · AlphaFold monomer V2.0 prediction for chromatin structure-remodeling complex subunit RSC4… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02206
- Elsewhere: RCSB PDB 2R10 · PDBe 2R10 · UniProt Q02206
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