MolNFT v1 · #49822 · protein
Crystal structure of ALIX/AIP1 in complex with the HIV-1 yplasl late domain
2R05 · Programmed cell death 6-interacting protein: “Crystal structure of ALIX/AIP1 in complex with the HIV-1 yplasl late domain”. X-ray diffraction, 8 pockets (best druggability 0.66). MolNFT v1 #49822 on GenesisL1: 3D structure, binding…
- PDB
- 2R05
- Type
- protein
- Length
- 708 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Programmed cell death 6-interacting protein; P6-gag
- UniProt
- Q8WUM4, P35962
- Pockets
- 8 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Programmed cell death 6-interacting protein | protein | 697 | 72% helix, 2% strand | Q8WUM4 |
| B | P6-gag | protein | 11 | 45% helix, 0% strand | P35962 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 205 | 0.66 | 0.85 | 24 | empty |
| 2 | 395 | 0.59 | 0.76 | 36 | empty |
| 3 | 267 | 0.55 | 0.76 | 27 | empty |
| 4 | 55 | 0.35 | 0.78 | 18 | empty |
| 5 | 73 | 0.32 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 587 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2R05 · Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLASL Late Domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WUM4 · AlphaFold monomer V2.0 prediction for programmed cell death 6-interacting protein (Q8WUM4) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WUM4
- Every structure of UniProt P35962
- Elsewhere: RCSB PDB 2R05 · PDBe 2R05 · UniProt Q8WUM4 · UniProt P35962
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