MolNFT v1 · #49761 · protein

Crystal structure of human epsinr enth domain

2QY7 · Clathrin interactor 1: “Crystal structure of human epsinr enth domain”. X-ray diffraction, 4 pockets (best druggability 0.68). MolNFT v1 #49761 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2QY7
Type: protein
Length: 408 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Clathrin interactor 1
UniProt: Q14677
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Clathrin interactor 1	protein	136	71% helix, 1% strand	Q14677

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	408	0.68	0.80	39	empty
2	147	0.51	0.79	22	empty
3	106	0.47	0.80	23	empty
4	53	0.31	0.76	11	empty

Interfaces

3 interfaces between chains.

A–B · 716 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 444 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 301 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

2QY7 · Crystal structure of human epsinR ENTH domain · the same entry in another collection · chain A against A, TM-score 1.00
Q14677 · AlphaFold monomer V2.0 prediction for clathrin interactor 1 (Q14677) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14677
Elsewhere: RCSB PDB 2QY7 · PDBe 2QY7 · UniProt Q14677

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