MolNFT v1 · #49759 · protein

Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domainm.

2QY2 · Probable mRNA-capping enzyme: “Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA…”. X-ray diffraction, 2 pockets (best druggability 0.77). MolNFT v1 #49759 on GenesisL1: 3D structure…

PDB: 2QY2
Type: protein
Length: 441 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable mRNA-capping enzyme
UniProt: Q5UQX1
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable mRNA-capping enzyme	protein	224	33% helix, 40% strand	Q5UQX1
B	Probable mRNA-capping enzyme	protein	217	33% helix, 35% strand	Q5UQX1

Ligands and binding sites

ACT · Acetate ion · additive · 2 copies · chains A
FLC · Citrate anion · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1115	0.77	0.79	92	ACT
2	384	0.60	0.76	51	empty

Interfaces

1 interface between chains.

A–B · 300 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

2QY2 · Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5UQX1
Elsewhere: RCSB PDB 2QY2 · PDBe 2QY2 · UniProt Q5UQX1

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