MolNFT v1 · #49737 · protein

Structure of nucleoporin NIC96

2QX5: “Structure of nucleoporin NIC96”. X-ray diffraction, 1 ligand (CL), 16 pockets (best druggability 0.52). MolNFT v1 #49737 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2QX5
Type: protein
Length: 1,138 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoporin NIC96
UniProt: P34077
Ligands: CL
Pockets: 16 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 68% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin NIC96	protein	569	69% helix, 2% strand	P34077
B	Nucleoporin NIC96	protein	569	66% helix, 2% strand	P34077

Ligands and binding sites

CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	87	0.52	0.84	16	empty
2	92	0.49	0.82	15	empty
3	101	0.45	0.79	16	empty
4	75	0.41	0.79	18	empty
5	108	0.40	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 543 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

2QX5 · Structure of nucleoporin Nic96 · the same entry in another collection · chain A against A, TM-score 1.00
P34077 · AlphaFold monomer V2.0 prediction for nucleoporin NIC96 (P34077) · a predicted model of the same protein · chain A against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P34077
Elsewhere: RCSB PDB 2QX5 · PDBe 2QX5 · UniProt P34077

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