MolNFT v1 · #49682 · protein
Crystal structure of a vesicular stomatitis virus nucleocapsid protein SER290TRP mutant
2QVJ: “Crystal structure of a vesicular stomatitis virus nucleocapsid protein SER290TRP mutant”. X-ray diffraction, 20 pockets (best druggability 0.72). MolNFT v1 #49682 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2QVJ
- Type
- protein
- Length
- 2,105 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleocapsid protein
- UniProt
- P03521
- Pockets
- 20 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Nucleocapsid protein | protein | 421 | 44% helix, 6% strand | P03521 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 177 | 0.72 | 0.89 | 20 | empty |
| 2 | 167 | 0.67 | 0.87 | 21 | empty |
| 3 | 228 | 0.66 | 0.84 | 23 | empty |
| 4 | 709 | 0.65 | 0.74 | 79 | empty |
| 5 | 326 | 0.64 | 0.80 | 43 | empty |
Interfaces
7 interfaces between chains.
- C–D · 2710 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 2567 Ų buried · 21 hydrogen bonds · protein-protein
- A–E · 2562 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 2547 Ų buried · 22 hydrogen bonds · protein-protein
- B–E · 328 Ų buried · 3 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03521
- Elsewhere: RCSB PDB 2QVJ · PDBe 2QVJ · UniProt P03521
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