MolNFT v1 · #49673 · protein

Crystal structure of drosophila melanogaster translin protein

2QVA · GM27569P: “Crystal structure of drosophila melanogaster translin protein”. X-ray diffraction, 6 pockets (best druggability 0.59). MolNFT v1 #49673 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2QVA
Type: protein
Length: 731 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GM27569P
UniProt: Q7JVK6
Pockets: 6 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 79% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D	GM27569P	protein	182	80% helix, 1% strand	Q7JVK6
C	GM27569P	protein	185	78% helix, 2% strand	Q7JVK6

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	359	0.59	0.76	36	empty
2	280	0.51	0.74	36	empty
3	55	0.35	0.79	20	empty
4	91	0.34	0.74	18	empty
5	70	0.30	0.73	11	empty

Interfaces

3 interfaces between chains.

B–C · 1782 Å² buried · 16 hydrogen bonds · protein-protein
A–D · 550 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 292 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

2QVA · Crystal structure of Drosophila melanogaster Translin protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7JVK6
Elsewhere: RCSB PDB 2QVA · PDBe 2QVA · UniProt Q7JVK6

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