MolNFT v1 · #49587 · protein

Structure of arabidopsis thaliana 5'-methylthioadenosine nucleosidase in apo form

2QSU: “Structure of arabidopsis thaliana 5'-methylthioadenosine nucleosidase in apo form”. X-ray diffraction, 2 pockets (best druggability 0.68). MolNFT v1 #49587 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2QSU
Type: protein
Length: 491 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-methylthioadenosine nucleosidase
EC: 3.2.2.16
UniProt: Q9T0I8
Pockets: 2 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5'-methylthioadenosine nucleosidase (EC 3.2.2.16)	protein	247	36% helix, 25% strand	Q9T0I8
B	5'-methylthioadenosine nucleosidase (EC 3.2.2.16)	protein	244	36% helix, 25% strand	Q9T0I8

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	118	0.68	0.90	27	empty
2	290	0.63	0.80	34	empty

Interfaces

1 interface between chains.

A–B · 2026 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

2QSU · Structure of Arabidopsis thaliana 5'-Methylthioadenosine nucleosidase in apo form · the same entry in another collection · chain A against A, TM-score 1.00
Q9T0I8 · AlphaFold monomer V2.0 prediction for 5'-methylthioadenosine nucleosidase (Q9T0I8) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9T0I8
Elsewhere: RCSB PDB 2QSU · PDBe 2QSU · UniProt Q9T0I8

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