MolNFT v1 · #49570 · protein
Crystal structure of the human retinoblastoma-binding protein 9 (rbbp-9). nesg target HR2978
2QS9: “Crystal structure of the human retinoblastoma-binding protein 9 (rbbp-9). nesg target HR2978”. X-ray diffraction, 3 pockets (best druggability 0.48). MolNFT v1 #49570 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2QS9
- Type
- protein
- Length
- 372 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Retinoblastoma-binding protein 9
- UniProt
- O75884
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Retinoblastoma-binding protein 9 | protein | 192 | 33% helix, 16% strand | O75884 |
| B | Retinoblastoma-binding protein 9 | protein | 180 | 33% helix, 17% strand | O75884 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.48 | 0.81 | 29 | empty |
| 2 | 216 | 0.48 | 0.75 | 26 | empty |
| 3 | 81 | 0.35 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 211 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 2QS9 · Crystal structure of the human retinoblastoma-binding protein 9 (RBBP-9). NESG target… · the same entry in another collection · chain A against A, TM-score 1.00
- O75884 · AlphaFold monomer V2.0 prediction for serine hydrolase RBBP9 (O75884) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75884
- Elsewhere: RCSB PDB 2QS9 · PDBe 2QS9 · UniProt O75884
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