MolNFT v1 · #49555 · protein
Crystal structure of a single chain trimer composed of the MHC I heavy chain H-2KB Y84A, beta-2MICROGLOBULIN, and ovalbumin-derived peptide.
2QRS · H-2 class I histocompatibility antigen K-B alpha chain…: “Crystal structure of a single chain trimer composed of the MHC I heavy chain H-2KB Y84A, beta-2MICROGLOBULIN…”. X-ray diffraction, 10 pockets (best druggability 0.66). MolNFT…
- PDB
- 2QRS
- Type
- protein
- Length
- 796 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- H-2 class I histocompatibility antigen K-B alpha chain, beta-2 microglobulin…
- UniProt
- P01901, Q91XJ8
- Pockets
- 10 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 19% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | H-2 class I histocompatibility antigen K-B alpha chain, beta-2 microglobulin, ovalbumin-derived peptide | protein | 398 | 19% helix, 38% strand | P01901, Q91XJ8 |
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 722 | 0.66 | 0.75 | 60 | empty |
| 2 | 721 | 0.66 | 0.75 | 57 | empty |
| 3 | 164 | 0.55 | 0.81 | 32 | empty |
| 4 | 170 | 0.53 | 0.79 | 35 | empty |
| 5 | 137 | 0.52 | 0.80 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 277 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 2QRS · Crystal Structure of a single chain trimer composed of the MHC I heavy chain H-2Kb Y84A… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01901
- Every structure of UniProt Q91XJ8
- Elsewhere: RCSB PDB 2QRS · PDBe 2QRS · UniProt P01901 · UniProt Q91XJ8
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