MolNFT v1 · #49463 · protein

Human EPHA3 kinase and juxtamembrane region, base, AMP-pnp bound structure

2QOQ · Ephrin receptor: “Human EPHA3 kinase and juxtamembrane region, base, AMP-pnp bound structure”. X-ray diffraction, 2 ligands (ANP, MG), 2 pockets (best druggability 0.59). MolNFT v1 #49463 on GenesisL1: 3D structure, binding sites…

PDB: 2QOQ
Type: protein
Length: 285 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ephrin receptor
EC: 2.7.10.1
UniProt: Q6P4R6
Ligands: ANP, MG
Pockets: 2 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ephrin receptor (EC 2.7.10.1)	protein	285	40% helix, 18% strand	Q6P4R6

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	314	0.59	0.78	37	MG, ANP
2	180	0.47	0.75	33	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

2QOQ · Human EphA3 kinase and juxtamembrane region, base, AMP-PNP bound structure · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6P4R6
Elsewhere: RCSB PDB 2QOQ · PDBe 2QOQ · UniProt Q6P4R6

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