MolNFT v1 · #49422 · protein
Kinase and ubiquitin-associated domains of MARK3/PAR-1
2QNJ · MAP/MICROTUBULE affinity-regulating kinase 3: “Kinase and ubiquitin-associated domains of MARK3/PAR-1”. X-ray diffraction, 6 pockets (best druggability 0.66). MolNFT v1 #49422 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2QNJ
- Type
- protein
- Length
- 640 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MAP/MICROTUBULE affinity-regulating kinase 3
- EC
- 2.7.11.1
- UniProt
- P27448
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MAP/MICROTUBULE affinity-regulating kinase 3 (EC 2.7.11.1) | protein | 318 | 41% helix, 15% strand | P27448 |
| B | MAP/MICROTUBULE affinity-regulating kinase 3 (EC 2.7.11.1) | protein | 322 | 41% helix, 15% strand | P27448 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.66 | 0.82 | 27 | empty |
| 2 | 336 | 0.66 | 0.80 | 45 | empty |
| 3 | 588 | 0.65 | 0.76 | 52 | empty |
| 4 | 116 | 0.38 | 0.74 | 20 | empty |
| 5 | 103 | 0.37 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 351 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2QNJ · Kinase and Ubiquitin-associated domains of MARK3/Par-1 · the same entry in another collection · chain A against A, TM-score 1.00
- P27448 · AlphaFold monomer V2.0 prediction for MAP/MICROTUBULE affinity- regulating kinase 3… · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27448
- Elsewhere: RCSB PDB 2QNJ · PDBe 2QNJ · UniProt P27448
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