MolNFT v1 · #49364 · protein
Crystal structure of activin receptor type II kinase domain from human
2QLU · Activin receptor type iib: “Crystal structure of activin receptor type II kinase domain from human”. X-ray diffraction, 2 ligands (ADE, SO4), 3 pockets (best druggability 0.66). MolNFT v1 #49364 on GenesisL1: 3D structure, binding…
- PDB
- 2QLU
- Type
- protein
- Length
- 297 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Activin receptor type iib
- EC
- 2.7.11.30
- UniProt
- Q13705
- Ligands
- ADE, SO4
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Activin receptor type iib (EC 2.7.11.30) | protein | 297 | 39% helix, 20% strand | Q13705 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 220 | 0.66 | 0.84 | 41 | SO4, ADE |
| 2 | 136 | 0.49 | 0.79 | 20 | empty |
| 3 | 77 | 0.45 | 0.82 | 18 | empty |
Compared structures
- 2QLU · Crystal structure of Activin receptor type II kinase domain from human · the same entry in another collection · chain A against A, TM-score 1.00
- Q13705 · AlphaFold monomer V2.0 prediction for activin receptor type-2B (Q13705) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13705
- Elsewhere: RCSB PDB 2QLU · PDBe 2QLU · UniProt Q13705
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