MolNFT v1 · #49330 · protein

Crystal structure of the 5TH PDZ domain of inad

2QKT · Inactivation-no-after-potential D protein: “Crystal structure of the 5TH PDZ domain of inad”. X-ray diffraction, 1 pocket (best druggability 0.52). MolNFT v1 #49330 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2QKT
Type: protein
Length: 170 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inactivation-no-after-potential D protein
UniProt: Q24008
Pockets: 1 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Inactivation-no-after-potential D protein	protein	85	13% helix, 42% strand	Q24008

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	138	0.52	0.80	15	empty

Interfaces

1 interface between chains.

A–B · 319 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2QKT · Crystal Structure of the 5th PDZ domain of InaD · the same entry in another collection · chain A against A, TM-score 1.00
Q24008 · AlphaFold monomer V2.0 prediction for inactivation-no-after-potential D protein (Q24008) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q24008
Elsewhere: RCSB PDB 2QKT · PDBe 2QKT · UniProt Q24008

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