MolNFT v1 · #4930 · protein
N153Q mutant of cytochrome F from chlamydomonas reinhardtii
1E2V: “N153Q mutant of cytochrome F from chlamydomonas reinhardtii”. X-ray diffraction, 1 ligand (HEC), 6 pockets (best druggability 0.83). MolNFT v1 #4930 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1E2V
- Type
- protein
- Length
- 753 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome F
- UniProt
- P23577
- Ligands
- HEC
- Pockets
- 6 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 10% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Cytochrome F | protein | 251 | 10% helix, 37% strand | P23577 |
Ligands and binding sites
- HEC · Heme C · ligand · 3 copies · chains A, C, B
- ACT · Acetate ion · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 850 | 0.83 | 0.86 | 119 | HEC |
| 2 | 191 | 0.69 | 0.87 | 40 | HEC |
| 3 | 60 | 0.33 | 0.76 | 13 | empty |
| 4 | 64 | 0.33 | 0.75 | 13 | empty |
| 5 | 53 | 0.31 | 0.76 | 13 | empty |
Interfaces
2 interfaces between chains.
- A–C · 552 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 152 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 6 cofactor (heme c attachment).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23577
- Elsewhere: RCSB PDB 1E2V · PDBe 1E2V · UniProt P23577
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