MolNFT v1 · #49204 · protein
Ubiquitin-conjugating enzyme E2Q
2QGX · Ubiquitin-conjugating enzyme E2 Q1: “Ubiquitin-conjugating enzyme E2Q”. X-ray diffraction, 6 pockets (best druggability 0.74). MolNFT v1 #49204 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2QGX
- Type
- protein
- Length
- 638 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2 Q1
- EC
- 6.3.2.19
- UniProt
- Q7Z7E8
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-conjugating enzyme E2 Q1 (EC 6.3.2.19) | protein | 156 | 40% helix, 20% strand | Q7Z7E8 |
| B | Ubiquitin-conjugating enzyme E2 Q1 (EC 6.3.2.19) | protein | 161 | 40% helix, 19% strand | Q7Z7E8 |
| C | Ubiquitin-conjugating enzyme E2 Q1 (EC 6.3.2.19) | protein | 161 | 40% helix, 19% strand | Q7Z7E8 |
| D | Ubiquitin-conjugating enzyme E2 Q1 (EC 6.3.2.19) | protein | 160 | 41% helix, 19% strand | Q7Z7E8 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 894 | 0.74 | 0.78 | 79 | empty |
| 2 | 287 | 0.62 | 0.80 | 47 | empty |
| 3 | 97 | 0.45 | 0.79 | 22 | empty |
| 4 | 68 | 0.38 | 0.78 | 17 | empty |
| 5 | 71 | 0.38 | 0.78 | 16 | empty |
Interfaces
5 interfaces between chains.
- C–D · 761 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 760 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 446 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 374 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 243 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z7E8
- Elsewhere: RCSB PDB 2QGX · PDBe 2QGX · UniProt Q7Z7E8
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