MolNFT v1 · #49174 · protein
Crystal structure of human TBC1 domain family member 22A
2QFZ: “Crystal structure of human TBC1 domain family member 22A”. X-ray diffraction, 1 ligand (UNX), 6 pockets (best druggability 0.82). MolNFT v1 #49174 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2QFZ
- Type
- protein
- Length
- 599 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TBC1 domain family member 22A
- UniProt
- Q8WUA7
- Ligands
- UNX
- Pockets
- 6 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TBC1 domain family member 22A | protein | 300 | 72% helix, 1% strand | Q8WUA7 |
| B | TBC1 domain family member 22A | protein | 299 | 73% helix, 1% strand | Q8WUA7 |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 12 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1106 | 0.82 | 0.84 | 104 | UNX |
| 2 | 101 | 0.39 | 0.76 | 18 | UNX |
| 3 | 95 | 0.39 | 0.76 | 18 | UNX |
| 4 | 81 | 0.36 | 0.76 | 17 | empty |
| 5 | 58 | 0.32 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1117 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WUA7
- Elsewhere: RCSB PDB 2QFZ · PDBe 2QFZ · UniProt Q8WUA7
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