MolNFT v1 · #4905 · protein

The high resolution structure of per-1 class a beta-lactamase

1E25 · Extended-spectrum beta-lactamase per-1: “The high resolution structure of per-1 class a beta-lactamase”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.54). MolNFT v1 #4905 on GenesisL1: 3D structure, binding sites…

PDB: 1E25
Type: protein
Length: 278 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Extended-spectrum beta-lactamase per-1
EC: 3.5.2.6
UniProt: P37321
Ligands: SO4
Pockets: 1 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Extended-spectrum beta-lactamase per-1 (EC 3.5.2.6)	protein	278	45% helix, 21% strand	P37321

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	254	0.54	0.77	31	SO4

Compared structures

1E25 · The high resolution structure of PER-1 class A beta-lactamase · the same entry in another collection · chain A against A, TM-score 1.00
P37321 · AlphaFold monomer V2.0 prediction for extended-spectrum beta- lactamase per-1 (P37321) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37321
Elsewhere: RCSB PDB 1E25 · PDBe 1E25 · UniProt P37321

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