MolNFT v1 · #48924 · protein

Crystal structure of the miz-1 BTB/POZ domain

2Q81 · Miz-1 protein: “Crystal structure of the miz-1 BTB/POZ domain”. X-ray diffraction, 3 pockets (best druggability 0.77). MolNFT v1 #48924 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2Q81
Type: protein
Length: 457 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Miz-1 protein
UniProt: Q13105
Pockets: 3 · best druggability 0.77

Structure

x-ray diffraction · 3 distinct chains · 59% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Miz-1 protein	protein	114	65% helix, 9% strand	Q13105
B	Miz-1 protein	protein	115	57% helix, 12% strand	Q13105
D	Miz-1 protein	protein	114	55% helix, 12% strand	Q13105

Ligands and binding sites

PG4 · Tetraethylene glycol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	442	0.77	0.85	49	empty
2	75	0.31	0.74	18	empty
3	62	0.31	0.75	17	empty

Interfaces

5 interfaces between chains.

A–B · 1321 Å² buried · 5 hydrogen bonds · protein-protein
C–D · 1312 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 800 Å² buried · 16 hydrogen bonds · protein-protein
A–D · 756 Å² buried · 11 hydrogen bonds · protein-protein
B–D · 187 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2Q81 · Crystal Structure of the Miz-1 BTB/POZ domain · the same entry in another collection · chain A against A, TM-score 1.00
Q13105 · AlphaFold monomer V2.0 prediction for zinc finger and btb domain- containing protein 17… · a predicted model of the same protein · chain D against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13105
Elsewhere: RCSB PDB 2Q81 · PDBe 2Q81 · UniProt Q13105

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