MolNFT v1 · #48920 · protein
Crystal structure of a putative phospho transferase (SP_1565) from streptococcus pneumoniae TIGR4 at 2.00 a resolution
2Q7X · UPF0052 protein SP_1565: “Crystal structure of a putative phospho transferase (SP_1565) from streptococcus pneumoniae TIGR4 at 2.00 a…”. X-ray diffraction, 1 ligand (CL), 7 pockets (best druggability 0.74). MolNFT v1 #48920 on…
- PDB
- 2Q7X
- Type
- protein
- Length
- 621 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- UPF0052 protein SP_1565
- UniProt
- Q97PN8
- Ligands
- CL
- Pockets
- 7 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | UPF0052 protein SP_1565 | protein | 316 | 38% helix, 21% strand | Q97PN8 |
| B | UPF0052 protein SP_1565 | protein | 305 | 39% helix, 21% strand | Q97PN8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 749 | 0.74 | 0.79 | 85 | CL |
| 2 | 256 | 0.53 | 0.75 | 29 | empty |
| 3 | 117 | 0.43 | 0.77 | 22 | empty |
| 4 | 115 | 0.37 | 0.74 | 14 | empty |
| 5 | 55 | 0.35 | 0.79 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1272 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 45 modified (methylation, engineered).
Compared structures
- 2Q7X · Crystal structure of a putative phospho transferase (sp_1565) from streptococcus… · the same entry in another collection · chain A against A, TM-score 1.00
- Q97PN8 · AlphaFold monomer V2.0 prediction for putative gluconeogenesis factor (Q97PN8) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q97PN8
- Elsewhere: RCSB PDB 2Q7X · PDBe 2Q7X · UniProt Q97PN8
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