MolNFT v1 · #48762 · protein

Beta-lactoglobulin (low humidity)

2Q39: “Beta-lactoglobulin (low humidity)”. X-ray diffraction, 6 pockets (best druggability 0.61). MolNFT v1 #48762 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2Q39
Type: protein
Length: 311 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-lactoglobulin
UniProt: P02754
Pockets: 6 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-lactoglobulin	protein	160	11% helix, 38% strand	P02754
B	Beta-lactoglobulin	protein	151	12% helix, 41% strand	P02754

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	178	0.61	0.82	33	empty
2	237	0.50	0.75	30	empty
3	55	0.50	0.87	17	empty
4	121	0.47	0.79	30	empty
5	52	0.39	0.81	16	empty

Interfaces

1 interface between chains.

A–B · 518 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2Q39 · Beta-lactoglobulin (low humidity) · the same entry in another collection · chain A against A, TM-score 1.00
P02754 · AlphaFold monomer V2.0 prediction for beta-lactoglobulin (P02754) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02754
Elsewhere: RCSB PDB 2Q39 · PDBe 2Q39 · UniProt P02754

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.