MolNFT v1 · #48653 · protein
2.2 a resolution crystal structure of UPF0201 protein from methanococcus jannaschii
2PZZ · UPF0201 protein MJ1564: “2.2 a resolution crystal structure of UPF0201 protein from methanococcus jannaschii”. X-ray diffraction, 1 pocket (best druggability 0.68). MolNFT v1 #48653 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2PZZ
- Type
- protein
- Length
- 482 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- UPF0201 protein MJ1564
- UniProt
- Q58959
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | UPF0201 protein MJ1564 | protein | 133 | 32% helix, 27% strand | Q58959 |
| B | UPF0201 protein MJ1564 | protein | 124 | 37% helix, 27% strand | Q58959 |
| C | UPF0201 protein MJ1564 | protein | 114 | 39% helix, 29% strand | Q58959 |
| D | UPF0201 protein MJ1564 | protein | 111 | 34% helix, 29% strand | Q58959 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 675 | 0.68 | 0.76 | 61 | empty |
Interfaces
3 interfaces between chains.
- A–C · 714 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 678 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 415 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 2PZZ · 2.2 A resolution crystal structure of UPF0201 protein from Methanococcus jannaschii · the same entry in another collection · chain D against D, TM-score 1.00
- Q58959 · AlphaFold monomer V2.0 prediction for UPF0201 protein MJ1564 (Q58959) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q58959
- Elsewhere: RCSB PDB 2PZZ · PDBe 2PZZ · UniProt Q58959
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