MolNFT v1 · #48651 · protein
Structure of the methuselah ectodomain with peptide inhibitor
2PZX · G-protein coupled receptor mth: “Structure of the methuselah ectodomain with peptide inhibitor”. X-ray diffraction, 6 pockets (best druggability 0.60). MolNFT v1 #48651 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2PZX
- Type
- protein
- Length
- 752 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G-protein coupled receptor mth
- UniProt
- O97148
- Pockets
- 6 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | G-protein coupled receptor mth | protein | 188 | 9% helix, 42% strand | O97148 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 445 | 0.60 | 0.75 | 54 | empty |
| 2 | 355 | 0.58 | 0.76 | 45 | empty |
| 3 | 66 | 0.32 | 0.75 | 15 | empty |
| 4 | 61 | 0.31 | 0.75 | 15 | empty |
| 5 | 52 | 0.28 | 0.75 | 14 | empty |
Interfaces
2 interfaces between chains.
- C–D · 542 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 537 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 2PZX · Structure of the methuselah ectodomain with peptide inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- O97148 · AlphaFold monomer V2.0 prediction for G-protein coupled receptor mth (O97148) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O97148
- Elsewhere: RCSB PDB 2PZX · PDBe 2PZX · UniProt O97148
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