MolNFT v1 · #48542 · protein
Structure of a mitochondrial type II peroxiredoxin from pisum sativum
2PWJ · Mitochondrial peroxiredoxin: “Structure of a mitochondrial type II peroxiredoxin from pisum sativum”. X-ray diffraction, 11 pockets (best druggability 0.65). MolNFT v1 #48542 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2PWJ
- Type
- protein
- Length
- 975 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial peroxiredoxin
- EC
- 1.11.1.15
- UniProt
- Q6KBB1
- Pockets
- 11 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, F | Mitochondrial peroxiredoxin (EC 1.11.1.15) | protein | 162 | 28% helix, 25% strand | Q6KBB1 |
| C, D, E | Mitochondrial peroxiredoxin (EC 1.11.1.15) | protein | 163 | 28% helix, 25% strand | Q6KBB1 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 349 | 0.65 | 0.80 | 44 | empty |
| 2 | 225 | 0.61 | 0.81 | 28 | empty |
| 3 | 234 | 0.61 | 0.81 | 30 | empty |
| 4 | 214 | 0.59 | 0.81 | 31 | empty |
| 5 | 103 | 0.45 | 0.79 | 18 | empty |
Interfaces
4 interfaces between chains.
- D–E · 849 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 841 Ų buried · 5 hydrogen bonds · protein-protein
- B–F · 840 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 380 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2PWJ · Structure of a mitochondrial type II peroxiredoxin from Pisum sativum · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6KBB1
- Elsewhere: RCSB PDB 2PWJ · PDBe 2PWJ · UniProt Q6KBB1
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