MolNFT v1 · #48483 · protein
Unprecedented activation mechanism of a non-canonical RNA-dependent RNA polymerase
2PUS · Ibdv VP1 RNA-dependant RNA polymerase: “Unprecedented activation mechanism of a non-canonical RNA-dependent RNA polymerase”. X-ray diffraction, 11 pockets (best druggability 0.77). MolNFT v1 #48483 on GenesisL1: 3D structure…
- PDB
- 2PUS
- Type
- protein
- Length
- 765 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ibdv VP1 RNA-dependant RNA polymerase
- UniProt
- Q9Q6Q5
- Pockets
- 11 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ibdv VP1 RNA-dependant RNA polymerase | protein | 765 | 45% helix, 15% strand | Q9Q6Q5 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1178 | 0.77 | 0.79 | 108 | empty |
| 2 | 138 | 0.59 | 0.84 | 19 | empty |
| 3 | 65 | 0.54 | 0.87 | 19 | empty |
| 4 | 150 | 0.52 | 0.79 | 24 | empty |
| 5 | 207 | 0.50 | 0.76 | 29 | empty |
Compared structures
- 2PUS · Unprecedented activation mechanism of a non-canonical RNA-dependent RNA polymerase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Q6Q5
- Elsewhere: RCSB PDB 2PUS · PDBe 2PUS · UniProt Q9Q6Q5
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