MolNFT v1 · #48442 · protein
Chicken src tyrosine kinase
2PTK · Tyrosine-protein kinase transforming protein src: “Chicken src tyrosine kinase”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #48442 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2PTK
- Type
- protein
- Length
- 426 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase transforming protein src
- EC
- 2.7.1.112
- UniProt
- P00523
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase transforming protein src (EC 2.7.1.112) | protein | 426 | 26% helix, 20% strand | P00523 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 729 | 0.73 | 0.79 | 69 | empty |
| 2 | 438 | 0.68 | 0.80 | 53 | empty |
| 3 | 387 | 0.65 | 0.79 | 49 | empty |
| 4 | 53 | 0.28 | 0.74 | 15 | empty |
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2PTK · Chicken src tyrosine kinase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00523
- Elsewhere: RCSB PDB 2PTK · PDBe 2PTK · UniProt P00523
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