MolNFT v1 · #48438 · protein
Phosphatidylinositol-specific phospholipase C mutant D198E
2PTD: “Phosphatidylinositol-specific phospholipase C mutant D198E”. X-ray diffraction, 1 pocket (best druggability 0.49). MolNFT v1 #48438 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2PTD
- Type
- protein
- Length
- 296 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol-specific phospholipase C
- EC
- 3.1.4.10
- UniProt
- P14262
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol-specific phospholipase C (EC 3.1.4.10) | protein | 296 | 31% helix, 20% strand | P14262 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.49 | 0.78 | 35 | empty |
Compared structures
- 2PTD · Phosphatidylinositol-specific phospholipase C mutant D198E · the same entry in another collection · chain A against A, TM-score 1.00
- P14262 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol phosphodiesterase (P14262) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14262
- Elsewhere: RCSB PDB 2PTD · PDBe 2PTD · UniProt P14262
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