MolNFT v1 · #48368 · protein
Crystal structure of Fab' from the HIV-1 neutralizing antibody 2F5
2PR4 · Nmab 2F5 Fab' heavy chain: “Crystal structure of Fab' from the HIV-1 neutralizing antibody 2F5”. X-ray diffraction, 2 pockets (best druggability 0.60). MolNFT v1 #48368 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2PR4
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nmab 2F5 Fab' heavy chain; Nmab 2F5 Fab' light chain
- Pockets
- 2 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Nmab 2F5 Fab' heavy chain | protein | 213 | 6% helix, 50% strand | — |
| H | Nmab 2F5 Fab' light chain | protein | 218 | 8% helix, 50% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 500 | 0.60 | 0.75 | 52 | empty |
| 2 | 69 | 0.29 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- L–H · 1778 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2PR4 · Crystal Structure of Fab' from the HIV-1 Neutralizing Antibody 2F5 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2PR4 · PDBe 2PR4
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