MolNFT v1 · #48347 · protein

Crystal structure of inactive ribosome inactivating protein from maize (B-32)

2PQG · Ribosome-inactivating protein 3: “Crystal structure of inactive ribosome inactivating protein from maize (B-32)”. X-ray diffraction, 3 pockets (best druggability 0.72). MolNFT v1 #48347 on GenesisL1: 3D structure, binding sites and…

PDB: 2PQG
Type: protein
Length: 510 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribosome-inactivating protein 3
EC: 3.2.2.22
UniProt: P25891
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribosome-inactivating protein 3 (EC 3.2.2.22)	protein	257	37% helix, 14% strand	P25891
B	Ribosome-inactivating protein 3 (EC 3.2.2.22)	protein	253	38% helix, 17% strand	P25891

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1001	0.72	0.75	73	empty
2	242	0.51	0.75	27	empty
3	174	0.43	0.74	27	empty

Interfaces

1 interface between chains.

A–B · 401 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

2PQG · Crystal structure of inactive ribosome inactivating protein from maize (b-32) · the same entry in another collection · chain A against A, TM-score 1.00
P25891 · AlphaFold monomer V2.0 prediction for ribosome-inactivating protein 3 (P25891) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25891
Elsewhere: RCSB PDB 2PQG · PDBe 2PQG · UniProt P25891

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