MolNFT v1 · #48250 · protein

Escherichia COLI prib E39A variant

2PNH · Primosomal replication protein N: “Escherichia COLI prib E39A variant”. X-ray diffraction, 2 pockets (best druggability 0.36). MolNFT v1 #48250 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2PNH
Type: protein
Length: 190 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Primosomal replication protein N
UniProt: P07013
Pockets: 2 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 71% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Primosomal replication protein N	protein	96	4% helix, 71% strand	P07013
B	Primosomal replication protein N	protein	94	3% helix, 70% strand	P07013

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	89	0.36	0.75	16	empty
2	70	0.31	0.74	20	empty

Interfaces

1 interface between chains.

A–B · 1409 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

2PNH · Escherichia coli PriB E39A variant · the same entry in another collection · chain A against A, TM-score 1.00
P07013 · AlphaFold monomer V2.0 prediction for primosomal replication protein N (P07013) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07013
Elsewhere: RCSB PDB 2PNH · PDBe 2PNH · UniProt P07013

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