MolNFT v1 · #47970 · protein

Crystal structure of human chloride intracellular channel protein 2

2PER: “Crystal structure of human chloride intracellular channel protein 2”. X-ray diffraction, 1 ligand (MNB), 1 pocket (best druggability 0.37). MolNFT v1 #47970 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2PER
Type: protein
Length: 222 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chloride intracellular channel protein 2
UniProt: O15247
Ligands: MNB
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chloride intracellular channel protein 2	protein	222	47% helix, 9% strand	O15247

Ligands and binding sites

MNB · 5-mercapto-2-nitro-benzoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.37	0.78	17	MNB

Modifications

Observed in the structure: 1 covalent, 1 disulfide (covalent ligand, disulfide).

Compared structures

2PER · Crystal Structure of Human Chloride Intracellular Channel protein 2 · the same entry in another collection · chain A against A, TM-score 1.00
O15247 · AlphaFold monomer V2.0 prediction for chloride intracellular channel protein 2 (O15247) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15247
Elsewhere: RCSB PDB 2PER · PDBe 2PER · UniProt O15247

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