MolNFT v1 · #47947 · protein

Crystal structure of frv operon protein frvx (PH1821)FROM pyrococcus horikoshii OT3

2PE3 · 354AA long hypothetical operon protein frv: “Crystal structure of frv operon protein frvx (PH1821)FROM pyrococcus horikoshii OT3”. X-ray diffraction, 15 pockets (best druggability 0.74). MolNFT v1 #47947 on GenesisL1: 3D structure…

PDB: 2PE3
Type: protein
Length: 1,318 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 354AA long hypothetical operon protein frv
UniProt: O59485
Pockets: 15 · best druggability 0.74

Structure

x-ray diffraction · 3 distinct chains · 28% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	354AA long hypothetical operon protein frv	protein	330	28% helix, 28% strand	O59485
B, C	354AA long hypothetical operon protein frv	protein	328	29% helix, 29% strand	O59485
D	354AA long hypothetical operon protein frv	protein	332	28% helix, 28% strand	O59485

Pockets

15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	330	0.74	0.86	35	empty
2	65	0.71	0.97	23	empty
3	400	0.61	0.76	39	empty
4	287	0.56	0.77	39	empty
5	301	0.56	0.76	38	empty

Interfaces

4 interfaces between chains.

A–D · 1855 Å² buried · 28 hydrogen bonds · protein-protein
A–B · 1186 Å² buried · 16 hydrogen bonds · protein-protein
A–C · 1171 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 1159 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

2PE3 · Crystal structure of Frv operon protein FRVX (PH1821)from pyrococcus horikoshii OT3 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O59485
Elsewhere: RCSB PDB 2PE3 · PDBe 2PE3 · UniProt O59485

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