MolNFT v1 · #47870 · protein

Crystal structure of the human tyrosine receptor phosphate gamma

2PBN · Receptor-type tyrosine-protein phosphatase gamma: “Crystal structure of the human tyrosine receptor phosphate gamma”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.48). MolNFT v1 #47870 on GenesisL1: 3D…

PDB: 2PBN
Type: protein
Length: 285 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-type tyrosine-protein phosphatase gamma
EC: 3.1.3.48
UniProt: P23470
Ligands: SO4
Pockets: 3 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase gamma (EC 3.1.3.48)	protein	285	40% helix, 24% strand	P23470

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.48	0.78	23	SO4
2	98	0.34	0.74	22	empty
3	55	0.30	0.76	10	empty

Compared structures

2PBN · Crystal structure of the human tyrosine receptor phosphate gamma · the same entry in another collection · chain A against A, TM-score 1.00
P23470 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase gamma… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23470
Elsewhere: RCSB PDB 2PBN · PDBe 2PBN · UniProt P23470

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