MolNFT v1 · #47828 · protein

Crystal structure of MJ0232 from methanococcus jannaschii

2PA6 · Enolase: “Crystal structure of MJ0232 from methanococcus jannaschii”. X-ray diffraction, 8 pockets (best druggability 0.76). MolNFT v1 #47828 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2PA6
Type: protein
Length: 854 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Enolase
EC: 4.2.1.11
UniProt: Q60173
Pockets: 8 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Enolase (EC 4.2.1.11)	protein	427	42% helix, 19% strand	Q60173

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	982	0.76	0.79	52	empty
2	476	0.69	0.80	65	empty
3	576	0.69	0.78	82	empty
4	95	0.47	0.81	20	empty
5	132	0.42	0.75	23	empty

Interfaces

1 interface between chains.

A–B · 1775 Å² buried · 38 hydrogen bonds · protein-protein

Compared structures

2PA6 · Crystal structure of MJ0232 from Methanococcus jannaschii · the same entry in another collection · chain A against A, TM-score 1.00
Q60173 · AlphaFold monomer V2.0 prediction for enolase (Q60173) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q60173
Elsewhere: RCSB PDB 2PA6 · PDBe 2PA6 · UniProt Q60173

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