MolNFT v1 · #47774 · protein

Crystal structure of the HIV-1 cross neutralizing monoclonal antibody 2F5 in complex with GP41 peptide elleldkwaslwn

2P8L · Nmab 2F5, light chain: “Crystal structure of the HIV-1 cross neutralizing monoclonal antibody 2F5 in complex with GP41 peptide…”. X-ray diffraction, 2 pockets (best druggability 0.56). MolNFT v1 #47774 on GenesisL1: 3D structure…

PDB: 2P8L
Type: protein
Length: 447 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nmab 2F5, light chain; Nmab 2F5, heavy chain; GP41 peptide
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 3 distinct chains · 5% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nmab 2F5, light chain	protein	214	5% helix, 50% strand	—
B	Nmab 2F5, heavy chain	protein	222	5% helix, 50% strand	—
C	GP41 peptide	protein	11	0% helix, 18% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	368	0.56	0.75	51	empty
2	58	0.28	0.74	17	empty

Interfaces

3 interfaces between chains.

A–B · 1801 Å² buried · 16 hydrogen bonds · protein-protein
B–C · 402 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 381 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

2P8L · Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2P8L · PDBe 2P8L

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.