MolNFT v1 · #47650 · protein
Crystal structure of the transcript cleavage factor, greb at 2.6A resolution
2P4V · Transcription elongation factor greb: “Crystal structure of the transcript cleavage factor, greb at 2.6A resolution”. X-ray diffraction, 17 pockets (best druggability 0.51). MolNFT v1 #47650 on GenesisL1: 3D structure, binding sites…
- PDB
- 2P4V
- Type
- protein
- Length
- 936 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription elongation factor greb
- UniProt
- P64273
- Pockets
- 17 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Transcription elongation factor greb | protein | 156 | 40% helix, 19% strand | P64273 |
Pockets
17 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 226 | 0.51 | 0.76 | 41 | empty |
| 2 | 178 | 0.49 | 0.77 | 31 | empty |
| 3 | 168 | 0.49 | 0.77 | 23 | empty |
| 4 | 105 | 0.42 | 0.77 | 22 | empty |
| 5 | 87 | 0.38 | 0.77 | 12 | empty |
Interfaces
6 interfaces between chains.
- E–F · 606 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 592 Ų buried · 4 hydrogen bonds · protein-protein
- D–F · 586 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 571 Ų buried · 4 hydrogen bonds · protein-protein
- D–E · 456 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2P4V · Crystal structure of the transcript cleavage factor, GreB at 2.6A resolution · the same entry in another collection · chain C against C, TM-score 1.00
- P64273 · AlphaFold monomer V2.0 prediction for transcription elongation factor greb (P64273) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P64273
- Elsewhere: RCSB PDB 2P4V · PDBe 2P4V · UniProt P64273
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